Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 ?M, respectively), leading to cell death.{14283} It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 ?M.{14282} Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-0.5 ?g/mL.{26087}
产品描述
A cyanobacterial toxin that targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 ?M, respectively), inhibits uridine monophosphate synthase complex activity (Ki = 10 ?M), and induces DNA damage
